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| Conjunctival Biopsy in Sarcoidosis |
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| 作者：Ying-Che… 文章来源：Uveitis Service, Department of Ophthalmology, National Yang Ming University school of Medicine and Taipei Veterans General Hospital, Taipei, Taiwan. 201, Sec.2 Shihpai Rd., Taipei 112-17, Taiwan. 点击数3830 更新时间：2006/7/11 18:31:06 文章录入：毛进 责任编辑：毛进 |
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| Purpose: Conjunctival biopsy is considered a simple, safe, and specific diagnostic procedure for sarcoidosis. This study was designed to determine the value of this procedure in Taiwan.
Methods:The study was conducted from December 2003 to April 2005 at the uveitis clinic, Taipei Veterans General Hospital. Blind sampling was conducted, obtaining a biopsy sample measuring 1 cm long by 3 mm width from both lower fornices. Positive result was defined as the presence of noncaseating granuloma while other granuloma-forming processes were excluded.
Results: Twenty nine patients (7 males and 22 females) were enrolled. Mean age at diagnosis was 47.8±12.4 years. The most common initial symptom was eye-related problems in 19 (65.5%) patients. Of 58 biopsies, 15 (25.9%) specimens in 11 (37.9%) patients proved positive. Four patients experienced bilateral involvement; 7 patients had unilateral involvement. No prominent conjunctival nodules or follicles were noted. Gender, age, presence of uveitis, initial symptoms, and chest condition comparisons revealed no association between positive and negative conjunctival biopsies.
Conclusions: Blind and bilateral conjunctival biopsy, due to its ease, safety, and specificity, could be the first biopsy in patients with clinical or chest X-ray abnormalities suggesting sarcoidosis. None of our positive biopsy patients had nodular lesions.
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